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Personally I dislike to read long stretches of text reversed out (e.g. white text on a dark or black background); how often do we see books set like this? It may well be appropriate for shorter stretches of text on-screen, but I find it very tiring to read for any length of time.
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Don’t set body text below 10 or 12px and, if possible, make it bigger. Remember, what’s legible on your 65” High Definition Plasma monitor, might not be so on a 15” MacBook. If in doubt, make it bigger.
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Let your type breathe. Don’t be afraid to leave blank spaces in your pages. This negative or white space will help focus attention on the text—and it’s the text that speaks loudest, so let it be heard. Next, remember the line-height CSS property; a good rule of thumb is line-spacing that’s at least 140% of your text size.Good type designers put a whole lot of effort into the micro white space the sits inside type. They spend countless hours attempting to achieve a balance between the black of the type and negative or white space that it envelops. Likewise, we should take time to consider the macro white space, the ‘voids’ that shape our blocks of text.